Thus, it is important when evaluating acidbase disorders to determine whether changes in p co 2 and hco 3. Understanding acidbase disorders ulster medical society. Simple algorithm of arterial blood gas analysis to ensure. Stepwise approach to interpreting the arterial blood gas. Acidbase disorders may occur as singular disorders, singular disorders with compensation, or a combination of disorders mixed acidbase disorders. Disclosure forms provided by the authors are available with the full text of this article at. Clinical approach to patients with acidbase disorders. An indepth knowledge of acidbase physiology is not essential for solving acidbase problems. A stepwise systematic approach can be used to determine the etiology and proper management of acidbase disorders. Accurate and timely interpretation of an acidbase disorder can be lifesav ing, but the establishment of a correct diagnosis may be challenging. In these mixed disorders, values may be deceptively normal. Physiological approach to assessment of acidbase disturbances. The physiological approach uses the carbonic acid bicarbonate buffer system. A stepwise approach to acidbase status interpretation.
Ikawalit approach to acid base disorders acidbase balance has earned a reputation as a difficult subject to understand. As with reading an electrocardiogram or a chest xray, it is important to use a system when reading arterial blood gases. Physicians should be able to interpret acid base disorders problems by following a systematic four step approach. Presented in a logical fashion, with proper attention paid to the basic physiologic and chemical principles involved, acid. Metabolic acidosis and metabolic alkalosis objectives by the end of this chapter, you should be able to. For those who wish, a detailed discussion of it can be found in costanzo. We presume that the patient has sepsis, a disease associated with lactic acidosis and respiratory alkalosis. Deviations of systemic acidity in either direction can impose adverse consequences and when severe can threaten life itself. Approach to acidbase disorders a clinical chemistry. Acidbase pathophysiology can be separated into metabolic or respiratory acidosis and alkalosis, as well as those disturbances that are compensated. The approach to identifying and managing acidbase disturbances should be a stepwise approach, as follows also see table 211.
Complex or mixed acidbase disturbances involve more than one primary process. Stepwise approach to interpreting the arterial blood gas 1. A stepwise approach for any acidbase problems in the step 2 ck exam 1. Approach to acidbase disorders a clinical chemistry perspective. I am going to present a structured approach to the identification of acidbase disorders based on a set of welldefined rules. We will not consider the use of these calculated indices further in this article. Utilize a systematic approach to evaluate acid base disturbances. Disorders of acidbase balance m aintenance of acidbase homeostasis is a vital function of the living organism. Approach to acidbase disorders a clinical chemistry perspective acidbase disorders are frequently encountered in clinical practice and have a significant impact on patient morbidity and mortality. The third step entails assessing the adequacy of the compensatory.
Open access simple algorithm of arterial blood gas analysis to ensure consistent, correct and quick responses. Acidbase disorders can usually be approached by following the steps outlined in the text and doing the calculations shown in the box on page 257. Sisson, md fast facts both an arterial blood gas and a basic metabolic panel are necessary to determine a patients acidbase status. Physiological approach to assessment of acid base disturbances. First, identify the primary disturbance based on the ph of arterial blood to determine if it is acidemic or alkalemic. Acidbase disorders made so easy even a caveman can do it lorraine r franzi, mshsm, rd, ldn, cnsd nutrition support specialist university of pittsburgh medical center pittsburgh, pa i. In mixed acidbase disorders deviations in pco2 and hco3. Complex acid base disturbances vanderbilt university medical. What i describe is the latest iteration of an approach we first described over 10 years ago4 and is built on the efforts of others. A quick stepwise approach that provides an individualized fluid plan for the patient is needed once it has been determined that fluid therapy may be beneficial.
For this purpose, a stepwise approach has been proposed by several authors 5053, and some simple concepts could help in supposing the presence of a mixed disorder. Understanding acidbase disorders a four step approach in order to understand the nature of an acidbase problem, we recommend a structured approach during which the following four questions should be asked. Acidbase disorders knowledge for medical students and. Learning objectives the clinician after participating in the roundtable will be able to. Diagnosis is made by arterial blood gas interpretation. No potential conflict of interest relevant to this article was reported.
This article provides readers with a stepwise approach for assessing abgs, as well as offering actual case examples to familiarize the reader with the concepts of acidbase disorders. This is followed by a discussion of primary respiratory acidosis and alkalosis and then metabolic causes of acidosis and alkalosis. Although the chemicalbiochemical basis of abb is important, this article aims to share a practical and. In their consensus statement on hyperglycemic crises in adult patients with diabetes, kitabchi et al. Stepwise approach to analysis of acidbase disorders 1. The third step in an evaluation is to consider the metabolic component of the acidbase disorder. Dr fall outlines a stepbystep approach to acidbase disorders, with em phasis on metabolic acidosis.
Understand the clinical approach to acidbase disorders, including the basic equation, questions to ask about each disorder, the use of venous electrolytes, arterial blood gases, and the acidbase. Acutechronic phase only with respiratory disorders. The corrected calcium is sufficient in most circumstances with acid base disorders and significantly altered albumin, the ionized calcium is more accurate. The following sixstep process helps ensure a complete interpretation of every abg. What is the likely clinical diagnosis based on history asa overdose mixed vomiting alkalosis copd with sepsis mixed resp and met acidosis copd with sepsis and vomiting triple acid base resp acidosis, gap acidosis and metabolic alkalosis copd with sepsis and diarrhea triple acid base. Analysis of acidbase disorders in patients with chronic. A practical approach to acidbase disorders that will help identify a majority of the disorders. The most clinical useful information comes from the clinical description of the patient by the history and physical examination. First, and most importantly, assessment of the patient must be completed to determine.
Practical patient evaluation for metabolic acidosis and other conditions. Hyperglycemic crises in adult patients with diabetes. Always analyze acidbase disturbance with both abg and venous electrolyte panel bmp 2. Acidbase homeostasis in man is accomplished by the maintenance of systemic arterial ph within a narrow range despite acid and alkaline loads originating from the daily intake and degradation of foods. A stepwise approach to acidbase disorders practical patient evaluation for metabolic acidosis and other conditions pamela j.
Most acidbase derangements do not benefit from specific correction of the abnormal ph. Pdf approach to acidbase disorders a clinical chemistry. Adhering to a system will allow you to identify the primary and compensatory process. Analysis of a patients acidbase disorder includes identification of the primary disorder, calculation of the anion gap ag, evaluation. Very often the presenting symptoms and signs give us a clue regarding the underlying acidbase disorder. Clinical approach to patients with acidbase disorders thomas d. Acidbase disorders msd manual professional edition. Fall dr fall is assistant professor of medicine, medical college of georgia school of medicine, and chief of nephrology, veterans affairs medical center, augusta, georgia. The traditional approach we used in groups 1 and 3 table 1 was. Abstract acidbase disorders can provide essential clues to underlying patient conditions.
Acidbase disorders are easily characterized using a stepwise approach. Acidbase homeostasis is fundamental for maintaining life. These conditions can be categorized as acidoses or alkaloses and have a respiratory or metabolic origin, depending on the cause of the imbalance. This article provides a simple, practical approach to identifying simple acidbase disorders and their compensatory mechanisms. Acidbase disorders frequently are encountered in the outpatient and especially in the inpatient setting. Although i appreciated their contribution of case studies and statistical analysis, i am in. Introduction disorders of acidbase balance can be found in as many as nine of every 10 patients in the icu, which means that acidbase disorders may be the most common clinical problems you will encounter in the icu. Ryan killian, pharmd, bcps assistant professor clinical pharmacy. The differential diagnosis, clinical findings, investigations, and treatments of hypercalcemia are discussed in this chapter. Because of this, acidbase disorders can be intimidating for many healthcare professionals. It is true that we did not use the approach suggested by dr bruno. Acid base homeostasis is fundamental for maintaining life. Acidbase disorders in patients with chronic obstructive. Furthermore, dr bruno proposed using a slightly modified traditional approach to detect mixed acidbase disorders.